Digenic variants in fibroblast growth factor 21 signaling linked to severe insulin resistance (Links to an external site)

Stone lab research was highlighted in Endocrine News. “We found that the proband carried mutations in the FGF21 receptor complex and performed tissue culture-based studies to demonstrate that these were functional/pathogenic mutations,” Stephen Stone, MD tells Endocrine News. “This study demonstrates the first ever link between FGF21 and severe insulin resistance.”